Copper depletion inhibits electron transport chain activity and nucleotide synthesis to boost leukemia therapy
Wong, A.Y.L., Myers, J.W., Prakash, G., Ma, A., Brook, J.R., Petrova, B., Bulut, B., White, R., Merz, C., de Souza, M., Maynard, A.G., Wang, P., Yu, A., Pohl, N.K., Weitman, M., Silverman, L.B., Perry, J.A., Stegmaier, K., Churchman, L.C., Cole, P.D., Brady, D., & Kanarek, N.
Nature Cancer (2026).
Exploring the role of nucleotide metabolism in adipogenesis
Pinette, J.A., Bryant, H.G., Myers, J.W., & Zaganjor, E.
Biochemical Society Transactions (2025).
Rhodoquinone is an electron carrier in the mammalian electron transport chain
Valeros, J., Jerome, M., Tseyang, T., Vo, P., Do, T., Palomino, D.C.F., Grotehans, N., Kunala, M., Jerrett, A.E., Hathiramani, N.R., Mireku, M., Magesh, R.Y., Yenilmez, B., Rosen, P.C., Mann, J.L., Myers, J.W., Kunchok, T., Manning, T., Carr, P., Boeker, L., Munim, M.B., Lewis, C.A., Sabatini, D.M., Kelly, M., Xie, J., Czech, M.P., Gao, G., Shepherd, J.N., Walker, A.K., Kim, H., Watson, E.V., & Spinelli, J.B.
Cell (2025).
Blocking purine biosynthesis prevents weight gain by upregulating thermogenic futile cycles
Myers, J.W., Park, W.Y., Eddie, A.M., Shinde, A.B., Murphy, A.C., Prasad, P., Montufar, C., Leonard, M.Z., Pinette, J.A., Rampy, J.J., Shaikh, Z., Hickman, T.T., Reynolds, G.N., Winn, N.C., Peck, S.H., Lantier, L., Coate, K.C., Stein, R.W., Carrasco, N., Calipari, E.S., McReynolds, M.R., & Zaganjor, E.
bioRxiv (2024).
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
Pinette, J.A., Myers, J.W., Park, W.Y., Bryant, H.G., Eddie, A.M., Wilson, G.A., Montufar, C., Shaikh, Z., Vue, Z., Nunn, E.R., Bessho, R., Cottam, M.A., Hasse, V.H., Hinton, A.O., Spinelli, J.B., Cartailler, J.P., & Zaganjor, E.
Journal of Lipid Research (2024).
Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis
Shinde, A.B., Nunn, E.R., Wilson, G.A., Chvasta, M.T., Pinette, J.A., Myers, J.W., Peck, S.H., Spinelli, J.B., & Zaganjor, E.
Journal of Biological Chemistry (2023).